Platform Leaders: Dr. Jean Bourbeau and Dr. Wan Tan

Goals

• To prospectively follow a cohort of > 1300 participants from the Canadian population to identify potentially modifiable risk factors for COPD besides cigarette smoking.
• To serve as a resource for multiple network studies and platforms

Publications

Aaron SD, Tan WC, Bourbeau J, Sin DD, Loves RH, MacNeil J, Whitmore GA; Canadian Respiratory Research Network. Diagnostic Instability and Reversals of

COPD Diagnosis in Subjects with Mild to Moderate Airflow Obstruction. Am J Respir Crit Care Med196(3): 306-314, 2017.

Borel B, Wilkinson-Maitland CA, Hamilton A, Bourbeau J, Perrault H, Jensen D, Maltais F. Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in COPD. Int J Chron Obstruct Pulmon Dis. 2016 Nov 29;11:2991-3000.

Tan WC, Hague CJ, Leipsic J, Bourbeau J, Zheng L, Li PZ, Sin DD, Coxson HO, Kirby M, Hogg JC, Raju R, Road J, O'Donnell DE, Maltais F, Hernandez P, Cowie R, Chapman KR, Marciniuk DD, FitzGerald JM, Aaron SD; Canadian Respiratory Research Network and the CanCOLD Collaborative Research group. Findings on Thoracic Computed Tomography Scans and Respiratory Outcomes in Persons with and without Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study. PLoS One. 2016 Nov 18;11(11).

Gupta N, Pinto L, Benedetti A, Li PZ, Tan WC, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL, Bourbeau J; Canadian Respiratory Research Network and the CanCOLD Collaborative Research Group. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations? Chest. 2016 Nov;150(5):1069-1079.

Sheridan JA, Zago M, Nair P, Li PZ, Bourbeau J, Tan WC, Hamid Q, Eidelman DH, Benedetti AL, Baglole CJ. Decreased expression of the NF-kappaB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respir Res. 2015;16:54.

Liu JC, Leung JM, Ngan DA, Nashta NF, Guillemi S, Harris M, Lima VD, Um SJ, Li Y, Tam S, Shaipanich T, Raju R, Hague C, Leipsic JA, Bourbeau J, Tan WC, Harrigan PR, Sin DD, Montaner J, Man SF. Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease. PLoS One. 2015;10:e0124426. (PMID= 25885433)

Undiagnosed COPD Contributes to the Burden of Health Care Utilization: Data from the CanCOLD Study.
Labonté LE, Tan WC, Li PZ, Mancino P, Aaron SD, Benedetti A, Chapman KR, Cowie R, FitzGerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Sin D, Bourbeau J; Canadian Respiratory Research Network and the CanCOLD Collaborative Research group. Undiagnosed COPD Contributes to the Burden of Health Care Utilization: Data from the CanCOLD Study. Am J Respir Crit Care Med. 2016 Feb 2.[Epub ahead of print]

Characteristics of COPD in never-smokers and ever smokers in the general population: results from the CanCOLD study
Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk D, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O’Donnell DE, Aaron SD, CanCOLD Collaborative Research Group. Characteristics of COPD in never-smokers and ever smokers in the general population: results from the CanCOLD study. Thorax 2015;70:822-9

Clinical relevance of fixed ratio vs lower limit of normal of FEV1/FVC in COPD: Patient-reported outcomes from the CanCOLD cohort
van Dijk WD, Tan W, Li PZ, Guo B, Li, S, Benedetti A, Bourbeau J, CanCOLD Study Group. Clinical relevance of fixed ratio vs lower limit of normal of FEV1/FVC in COPD: Patient-reported outcomes from the CanCOLD cohort. Annals of family medicine. 2015 Jan/Feb; 13 (1): 41-48

Exacerbations in non-COPD patients: truth or myth-authors' response
Tan WC, Bourbeau J, Aaron S, FitzGerald JM, Hernandez P, Cowie R, Chapman KR, Marciniuk D, Maltais F, Buist S, O'Donnell D, Sin DD; CanCOLD Collaborative Research Group. Exacerbations in non-COPD patients: truth or myth-authors' response. Thorax. 2014 Nov; 69(11).

The COPD assessment test: a systematic review
Gupta N, Pinto LM, Morogan A, Bourbeau J. The COPD assessment test: a systematic review. Eur Respir J. 2014 Oct;44(4):873-84

Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study
Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, O'Donnell DE, Sin DD, Aaron SD, CanCOLD Collaborative Research Group. Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study. Thorax. 2014 Aug;69(8):709-17.