Publications

Schaeffer MR, Ryerson CJ, Ramsook AH, Wilkie SS, Molgat-Seon Y, Dhillon SS, Mitchell RA, Sheel AW, Khalil N, Camp PG, Guenette JA. Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease.  Eur Respir J, In Press.

Ramsook AH, Molgat-Seon Y, Schaeffer MR, Syed N, Wilkie SS, Camp PG, Reid WD, Romer LM, Guenette JA. Effects of inspiratory muscle training on respiratory muscle electromyography and dyspnoea during exercise in healthy men. J Appl Physiol 2017; 122:1267-1275.

Ramsook AH, Mitchell RA, Bell T, Calli S, Kennedy C, Lehman J, Thompson M, Dhillon S, Guenette JA. Is parasternal intercostal EMG an accurate surrogate of respiratory neural drive and biomarker of dyspnea during cycle exercise testing? Respir Physiol Neurobiol 2017; 242: 40-44.

Elbehairy AF, Faisal A, Guenette JA, Jensen D, Webb KA, Neder JA, O’Donnell DE; the Canadian Respiratory Research Network. Resting physiological markers of exercise intolerance in smokers with a normal FEV₁. COPD 2017: 14(3): 267-275.

O’Donnell DE, Elbehairy AF, Berton DC, Domnik NJ, Neder JA; on behalf of the Canadian Respiratory Research Network (CRRN). Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung disease. Front Physiol 2017; 8: 82.

Mazzuco A, Medeiros WM, Souza AS, Alencar MCN, Neder JA, Borghi-Silva A. Are heart rate dynamics in the transition from rest to submaximal exercise related to maximal cardiorespiratory responses in COPD? Braz J Phys Ther. 2017 Jul - Aug;21(4):251-258. doi: 10.1016/j.bjpt.2017.05.002. Epub 2017 May 20. PubMed PMID: 28558953; PubMed Central PMCID: PMC5537469.

O'Donnell DE, Elbehairy AF, Webb KA, Neder JA; Canadian Respiratory Research Network. The Link between Reduced Inspiratory Capacity and Exercise Intolerance in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S30-S39. doi: 10.1513/AnnalsATS.201610-834FR. PubMed PMID: 28398073.

Neder JA, Berton D, Muller P, Elbehairy A, Rocha A, Palange P, O’Donnell DE; on behalf of the Canadian Respiratory Research Network (CRRN). Ventilatory inefficiency and exertional dyspnea in early Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Jul 14(Supplemnetn_1):S22-S29. doi: 10.1513/AnnalsATS.201612-1033FR

Elbehairy AF, Parraga G, Webb KA, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network CRRN). Mild chronic obstructive pulmonary disease: Why spirometry is not sufficient! Expert Rev Respir Dis,2017 Jul 11(7):549-563. doi: 10.1080/17476348.2017.1334553. Epub 2017 June 5.

Rocha A, Arbex FF, Sperandio PA, Souza A, Biazzim L, Mancuso F, Berton DC, Hochhegger B, Alencar MCN, Nery LE, O'Donnell DE, Neder JA. Excess Ventilation in COPD-heart Failure Overlap: Implications for Dyspnea and Exercise Intolerance. Am J Respir Crit Care Med. 2017 Jun 30. doi: 10.1164/rccm.201704-0675OC. [Epub ahead of print] PubMed PMID: 28665692.

Abdallah SJ, Chan D.S., Glicksman R, Mendonca CT, Luo Y, Bourbeau J, Smith BM, Jensen D.  Abdominal binding improves neuromuscular efficiency of the human diaphragm during exercise. Frontiers in Physiology: Respiratory Physiology, published online May 31, 2017 as doi: 10.3389/fphys.2017.00345

Hirai DM, Jones JH, Zelt JT, da Silva ML, Bentley RF, Edgett BA, Gurd BJ, Tschakovsky ME, O'Donnell DE, Neder JA. Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease. J Appl Physiol (1985). 2017 May 1;122(5):1351-1361. doi: 10.1152/japplphysiol.00990.2016. Epub 2017 Mar 2. PubMed PMID: 28255088.

Jones JH, Zelt JT, Hirai DM, Diniz CV, Zaza A, O'Donnell DE, Neder JA. Emphysema on Thoracic CT and Exercise Ventilatory Inefficiency in Mild-to-Moderate COPD. COPD. 2017 Apr;14(2):210-218. doi: 10.1080/15412555.2016.1253670. Epub 2016 Dec 20. PubMed PMID: 27997255.

Elbehairy AF, Faisal A, Guenette JA, Jensen D, Webb KA, Ahmed R, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Resting physiological correlates of reduced exercise capacity in smokers with mild airway obstruction. COPD, published online April 3, 2017 as doi: 10.1080/15412555.2017.1281901

Neder JA, Berton DC, Arbex FF, Alencar MC, Rocha A, Sperandio PA, Palange P, O'Donnell DE. Physiological and clinical relevance of exercise ventilator efficiency in COPD. Eur Respir J. 2017 Mar 8;49(3). pii: 1602036. doi: 10.1183/13993003.02036-2016. Print 2017 Mar. Review. PubMed PMID: 28275174.

Walter Barbosa G, Neder JA, Utida K, O'Donnell DE, de Tarso Müller P. Impaired exercise ventilatory efficiency in smokers with low transfer factor but normal spirometry. Eur Respir J. 2017 Mar 8;49(3). pii: 1602511. doi: 10.1183/13993003.02511-2016. Print 2017 Mar. PubMed PMID: 28275177.

Davis C, Pike D, Svenningsen S, McCormack DG, O’Donnell DE, Neder JA, Parraga G. Ventilation heterogeneity in older never-smokers and ex-smokers with COPD: the poorly communicating fraction and MRI ventilation defects. Academic Radiology 2016; 23(4): 398-405.

Currow DC, Abernathy AP, Allcroft P, Banzett RB, Bausewein C, Booth S, Carrieri-Kohlman V, Davidson P, Disler R, Donesky D, Dudgeon D, Ekstrom M, Farquhar M, Higginson I, Janssen D, Jensen D, Jolley C, Krajnik M, Laveneziana P, McDonald C, Maddocks M, Morelot-Panzini C, Moxham J, Mularski RA, Noble S, O'Donnell DE, Parshall MB, Pattinson K, Phillips J, Ross J, Schwartzstein RM, Similowski T, Simon S, Smith T, Wells A, Yates P, Yorke J, Johnson MJ.  The need to research refractory breathlessness. Eur Respir J 2016; 47(1): 342-343.

Gupta N, Pinto L, Benedetti A, Li PZ, Tan WC, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL, Bourbeau J; Canadian Respiratory Research Network and the CanCOLD Collaborative Research Group. The COPD Assessment Test: Can it discriminate across COPD subpopulations? Chest 2016; 150(5): 1069-1079.

Borel B, Wilkinson-Maitland C, Hamilton AL, Perrault H, Bourbeau J, Jensen D, Maltais F.  Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in moderate-to-severe COPD. Int J COPD 2016; 11: 2991-3000.

O’Donnell DE, Neder JA, Elbehairy AF. Physiological impairment in mild COPD [review]. Respirology 2016; 21(2): 211-22.

Quon BS, Wilkie SS, Ramsook AH, Schaeffer MR, Puyat JH, Wilcox PG, Guenette JA.  Qualitative dimensions of exertional dyspnea in adults with cystic fibrosis.  J Appl Physiol 2016; 121: 449-456.

Ramsook AH, Koo R, Molgat-Seon Y, Dominelli PB, Syed N, Ryerson CJ, Sheel AW, Guenette JA.  Diaphragm recruitment increases during a bout of targeted inspiratory muscle training.  Med Sci Sports Exerc 2016; 48: 1179-1186.

Elbehairy AF, Guenette JA, Faisal A, Ciavaglia CE, Webb KA, Jensen D, Ramsook AH, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Mechanisms of exertional dyspnea in symptomatic smokers without COPD. Eur Respir J 2016; 48: 695-705.

Alencar MC, Arbex FF, Souza A, Mazzuco A, Sperandio PA, Rocha A, Hirai DM, Mancuso F, Berton DC, Borghi-Silva A, Almeida D, OʼDonnel DE, Neder JA. Does Exercise Ventilatory Inefficiency Predict Poor Outcome in Heart Failure Patients With COPD? J Cardiopulm Rehabil Prev. 2016 Nov/Dec;36(6):454-459. PubMed PMID: 27779551.

Rodrigues A, Di Martino M, Nellessen AG, Hernandes NA, Neder JA, Pitta F. Is  the six-minute walk test a useful tool to prescribe high-intensity exercise in patients with chronic obstructive pulmonary disease? Heart Lung. 2016 Nov - Dec;45(6):550-556. doi: 10.1016/j.hrtlng.2016.08.005. Epub 2016 Sep 14. PubMed PMID: 27639286.

Arbex FF, Alencar MC, Souza A, Mazzuco A, Sperandio PA, Rocha A, Hirai DM, Mancuso F, Berton DC, Borghi-Silva A, Almeida DR, O'Donnell DE, Neder JA. Exercise Ventilation in COPD: Influence of Systolic Heart Failure. COPD. 2016 Dec;13(6):693-699. Epub 2016 May 12. PubMed PMID: 27172093.

Rocha A, Arbex FF, Alencar MC, Sperandio PA, Hirai DM, Berton DC, O'Donnell DE, Neder JA. Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD. Int J Cardiol. 2016 Dec 1;224:447-453. doi: 10.1016/j.ijcard.2016.09.077. Epub 2016 Sep 24. PubMed PMID: 27701063.

Neder JA, Chiavegato LD. High oxygen extraction and slow recovery of muscle deoxygenation kinetics afterneuromuscular electrical stimulation in COPD patients. Eur J Appl Physiol. 2016 Oct;116(10):1899-910. doi: 10.1007/s00421-016-3442-7. Epub 2016 Jul 28. PubMed PMID: 27468840.

O'Donnell DE, Elbehairy AF, Faisal A, Webb KA, Neder JA, Mahler DA. Exertional dyspnoea in COPD: The clinical utility of cardiopulmonary exercise testing. Eur Respir Rev. 2016 Sep;25(141):333-47. doi: 10.1183/16000617.0054-2016. Review. Erratum in: Eur Respir Rev. 2016 Dec;25(142):513. PubMed PMID: 27581832.

Souza AS, Sperandio PA, Mazzuco A, Alencar MC, Arbex FF, Oliveira MF, O'Donnell DE, Neder JA. Influence of heart failure on resting lung volumes in patients with COPD. J Bras Pneumol. 2016 Jul-Aug;42(4):273-278. doi: 10.1590/S1806-37562015000000290. English, Portuguese. PubMed PMID: 27832235; PubMed Central PMCID: PMC5063444.

Neder JA, Alharbi A, Berton DC, Alencar MC, Arbex FF, Hirai DM, Webb KA, O'Donnell DE. Exercise Ventilatory Inefficiency Adds to Lung Function in Predicting Mortality in COPD. COPD. 2016 Aug;13(4):416-24. doi: 10.3109/15412555.2016.1158801. Epub 2016 Apr 14. PubMed PMID: 27077955.

Oliveira MF, Arbex FF, Alencar MC, Souza A, Sperandio PA, Medeiros WM, Mazzuco A, Borghi-Silva A, Medina LA, Santos R, Hirai DM, Mancuso F, Almeida D, O'Donnell DE, Neder JA. Heart Failure Impairs Muscle Blood Flow and Endurance Exercise Tolerance in COPD. COPD. 2016 Aug;13(4):407-15. doi: 10.3109/15412555.2015.1117435. Epub 2016 Jan 20. PubMed PMID: 26790095.

Berton DC, de Castro MA, Merola P, Benedetto I, Castilho M, Vieira PJ, Knorst MM, Neder JA. Inspiratory loading and limb blood flow in COPD: The modulating effects of resting lung hyperinflation. Respir Physiol Neurobiol. 2016 Jul;228:25-9. doi: 10.1016/j.resp.2016.03.004. Epub 2016 Mar 7. PubMed PMID: 26965088.

O'Donnell DE, Webb KA, Harle I, Neder JA. Pharmacological management of breathlessness in COPD: recent advances and hopes for the future. Expert Rev Respir Med. 2016 Jul;10(7):823-34. doi: 10.1080/17476348.2016.1182867. Epub 2016 May 12. Review. PubMed PMID: 27115291.

Davis C, Sheikh K, Pike D, Svenningsen S, McCormack DG, O'Donnell D, Neder JA, Parraga G; Canadian Respiratory Research Network. Ventilation Heterogeneity in Never-smokers and COPD:: Comparison of Pulmonary Functional Magnetic Resonance Imaging with the Poorly Communicating Fraction Derived From Plethysmography. Acad Radiol. 2016 Apr;23(4):398-405. doi: 10.1016/j.acra.2015.10.022. Epub 2016 Jan 8. PubMed PMID: 26774739.

Dominelli P, Foster GE, Guenette JA, Haverkamp H, Eves ND, Dominelli GS, Henderson WR, O’Donnell DE, Sheel AW. Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD. Respir Physiol Neurobiol 2015; 219: 30-5.

O’Donnell DE, Neder JA, Webb KA, Elbehairy AF. Reply: Effects of mild chronic obstructive pulmonary disease on gas exchange during cycling and walking [letter]. Am J Respir Crit Care Med 2015; 192(9): 1138-9.

Pulmonary gas exchange abnormalities in mild COPD: implications for exercise intolerance
Elbehairy AF, Ciavaglia CE, Webb KA, Guenette JA, Jensen D, Mourad SM, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Pulmonary gas exchange abnormalities in mild COPD: implications for exercise intolerance. Am J Respir Crit Care Med published online March 31, 2015 as doi: 10.1164/rccm.201501-0157OC.

Effect of age-related ventilatory inefficiency on respiratory sensation during exercise
Faisal A, Webb KA, Guenette JA, Jensen D, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Effect of age-related ventilatory inefficiency on respiratory sensation during exercise. Respir Physiol Neurobiol 2015; 205: 129-139. [doi:10.1016/j.resp.2014.10.017]

Physiological characterization of the chronic bronchitis phenotype in GOLD grade 1B COPD
Elbehairy A, Raghavan N, Cheng S, Yang L, Webb KA, Neder JA, Guenette JA, Mahmoud MI, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Physiological characterization of the chronic bronchitis phenotype in GOLD grade 1B COPD. Chest published online November 13, 2014 as doi: 10.1378/chest.14-1491.